Protein Degradation: Homeostasis, Stress, and Therapy
*Corresponding Author: Pavel Nov脙隆k, Department of Cellular Regulation Prague Institute of Molecular Science, Czech Republic, Email: p.novak@demo.czReceived Date: Nov 03, 2025 / Published Date: Dec 01, 2025
Citation: Novák P (2025) Protein Degradation: Homeostasis, Stress, and Therapy. cmb 71: 417.DOI: 10.4172/1165-158X.1000417
Copyright: © 2025 Pavel Novák This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Protein degradation pathways, including the ubiquitin-proteasome system (UPS) and autophagy, are fundamental for cellular health and disease. This review explores their intricate mechanisms, from general degradation to specialized processes like mitophagy and ER-associated degradation (ERAD). Cellular stress activates autophagy, while E3 ligases like CRLs regulate cell cycle control. Targeted protein degradation (TPD) offers therapeutic opportunities, particularly in neurodegenerative diseases and cancer. The UPS also plays a critical role in inflammatory signaling. Selective autophagy mechanisms ensure precise removal of cellular targets.
