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Redox Homeostasis Dysregulation in Noise-Induced Hearing Loss: Oxidative Stress and Antioxidant Treatmen

Received Date: Feb 28, 2025 / Published Date: Mar 30, 2025

Citation: Beatrice G (2025) Redox Homeostasis Dysregulation in Noise-Induced Hearing Loss: Oxidative Stress and Antioxidant Treatment. Otolaryngol (Sunnyvale) 15: 630.DOI: 10.4172/2161-119X.1000630

Copyright: © 2025 Beatrice G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Noise-induced hearing loss (NIHL) is a prevalent occupational and recreational health concern, driven by irreversible damage to cochlear structures following excessive noise exposure. Emerging evidence highlights the critical role of redox homeostasis dysregulation in NIHL pathogenesis, where oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, triggers cellular damage in the auditory system. This article explores the mechanisms underlying redox dysregulation in NIHL, focusing on the generation of ROS, the depletion of endogenous antioxidants, and the subsequent cascade of cochlear injury. Additionally, we evaluate the therapeutic potential of antioxidant treatments in mitigating oxidative damage and preserving hearing function. Through a synthesis of preclinical and clinical studies, we discuss the efficacy of antioxidants such as N-acetylcysteine (NAC), vitamins C and E, and glutathione in restoring redox balance and preventing NIHL progression. Our findings underscore the importance of targeting oxidative stress as a viable strategy for NIHL prevention and treatment, while highlighting gaps in current research that warrant further investigation.