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Role of Topical Antibiotic Ointment in the Lateral Graft Following Underlay Myringoplasty: A Prospective Randomized Study

Received Date: Feb 28, 2025 / Published Date: Mar 30, 2025

Citation: Beatrice G (2025) Role of Topical Antibiotic Ointment in the Lateral Graft Following Underlay Myringoplasty A Prospective Randomized Study. Otolaryngol (Sunnyvale) 15: 631.DOI: 10.4172/2161-119X.1000631

Copyright: © 2025 Beatrice G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Objective: This study aimed to evaluate the role of topical antibiotic ointment in enhancing graft success and reducing postoperative infection rates following underlay myringoplasty with a lateral graft technique for chronic tympanic membrane perforations. Methods: A prospective randomized controlled trial was conducted involving 135 patients with chronic tympanic membrane perforations. Participants were randomized into two groups: the use of antibiotic ointment (UAO) group (n=68), where topical antibiotic ointment was applied to the external auditory canal (EAC) post-surgery, and the no antibiotic ointment (NAO) group (n=67), where no ointment was used. All patients underwent endoscopic underlay myringoplasty with a cartilage-perichondrium graft. Primary outcomes included graft success rate and postoperative infection rate, assessed at 6 months post-surgery. Secondary outcomes included complications such as graft lateralization or blunting. Statistical analysis was performed using chi-square tests to compare outcomes between groups. Results: At 6 months, the graft success rate was 92.6% in the UAO group and 91.0% in the NAO group (P=0.979), showing no significant difference. The postoperative infection rate was 4.4% in the UAO group and 10.4% in the NAO group (P=0.312), also not statistically significant. No significant differences were observed in complications such as graft lateralization or blunting between the groups. Conclusion: The application of topical antibiotic ointment in the EAC following underlay myringoplasty with a lateral graft did not significantly improve graft success or reduce postoperative infection rates. These findings suggest that routine use of topical antibiotics may not be necessary in this surgical context, challenging traditional practices and highlighting the need for further research into optimal postoperative care strategies.