中国P站

Abstract

Single-cell spatial transcriptomics and RNA sequencing studies have revolutionized our understanding of infection and inflammatory diseases. These technologies dissect cell-type-specific responses in various human tissues infected with viruses like Influenza A, Severe Acute Respiratory Syndrome Coronavirus 2, Herpes Simplex, and bacteria like Staphylococcus aureus, as well as parasitic infections. Key findings include immune cell dysregulation, host immune heterogeneity, inflammation, metabolic reprogramming, and pulmonary vascular pathology. These granular insights reveal critical cellular mechanisms, offering novel diagnostic biomarkers and therapeutic targets for diverse infectious conditions.