中国P站

Abstract

Kidney transplant recipients (KTRs) face a markedly increased risk of developing cutaneous squamous cell carcinoma (cSCC), particularly in sun-exposed areas such as the scalp. Due to chronic immunosuppression, cSCC in this population often demonstrates more aggressive behavior, increased recurrence rates, and higher metastatic potential compared to immunocompetent individuals. To review and summarize current evidence and best practices in the management of scalp cSCC in kidney transplant recipients, emphasizing treatment modalities, immunosuppression considerations, and interdisciplinary care. A comprehensive review of recent literature and clinical guidelines was conducted to assess surgical and non-surgical management strategies for scalp cSCC in KTRs. Particular attention was given to tumor behavior, risk stratification, immunosuppressive regimen adjustment, and long-term surveillance. Management of scalp cSCC in KTRs requires a nuanced approach. Mohs micrographic surgery remains the gold standard for localized lesions, providing tissue-sparing yet effective excision. High-risk or advanced cases may benefit from adjuvant radiotherapy or systemic treatments, including immune checkpoint inhibitors, with careful monitoring of allograft function. Immunosuppression minimization or conversion to mTOR inhibitors may help reduce tumor progression without compromising graft viability. Scalp cSCC in kidney transplant recipients is a high-risk condition necessitating vigilant surveillance and individualized treatment. A multidisciplinary approach integrating dermatology, oncology, transplant medicine, and surgery is essential for optimizing patient outcomes while preserving graft function.