中国P站

Abstract

T cell exhaustion significantly impairs immune responses in chronic infections and cancer, marked by functional deficits and
altered metabolic and epigenetic profiles. Therapeutic strategies are emerging to reverse exhaustion, leveraging the plasticity of these
cells. Key areas of focus include metabolic reprogramming, epigenetic control, the tumor microenvironment, cytokine signaling,
and exhausted T cell heterogeneity. Understanding the interplay of these factors and the reversibility of exhaustion is crucial for
developing novel immunotherapies targeting metabolic enzymes, epigenetic modifiers, and immune checkpoints to restore anti-tumor
and anti-viral immunity.