Targeting Gynecologic Cancer Angiogenesis: Pathways and Therapies
Received Date: Dec 01, 2025 / Published Date: Dec 29, 2025
Abstract
Angiogenesis is crucial for gynecologic cancer growth and metastasis. Targeting this process offers therapeutic potential. VEGF is a key driver, with anti-VEGF therapies showing clinical benefit. Resistance mechanisms, alternative pathways (angiopoietins, HIFs), microRNAs, and the tumor microenvironment are important considerations. Novel strategies include targeting endothelial cells, proangiogenic cells, and metabolic pathways. Combination therapies are vital for overcoming resistance and improving survival.
Citation: Green DN (2025) Targeting Gynecologic Cancer Angiogenesis: Pathways and Therapies. Current Trends Gynecol Oncol 10: 307
Copyright: 漏 2025 Dr. Noah Green This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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