中国P站

Abstract

The gut microbiota plays a crucial role in modulating mucosal immunity, impacting both inflammatory diseases and autoimmune disorders. This complex interplay involves a delicate balance between commensal bacteria and the immune system, influencing immune tolerance and inflammatory responses. Disruptions in microbial composition, termed dysbiosis, have been linked to conditions such as inflammatory bowel disease (IBD), rheumatoid arthritis, and type 1 diabetes. Understanding the mechanisms through which gut microbiota interact with mucosal immunity can offer new therapeutic avenues for managing these conditions. Recent advances highlight the roles of specific microbial metabolites, pattern recognition receptors, and immune cell modulation in shaping host immunity. This review explores current research on gut microbiota-immune system interactions and their implications for disease development and treatment. Targeted microbial interventions, including probiotics, prebiotics, and fecal microbiota transplantation, hold promise in restoring immune balance. Further research is needed to elucidate precise microbial-host interactions to develop Janel treatment strategies.