中国P站

Abstract

Nociceptive pain, one of the most fundamental forms of pain, arises from the activation of peripheral nociceptors in response to actual or threatened tissue injury. Unlike neuropathic pain, which stems from damage to the nervous system itself, nociceptive pain is a physiological process crucial for survival. Despite its protective function, persistent or exaggerated nociceptive signaling can lead to chronic pain and disability. Understanding the complex pathophysiological mechanisms of nociceptive pain—ranging from transduction at the peripheral terminals of sensory neurons to central processing in the spinal cord and brain—has paved the way for the development of targeted pharmacological interventions. This article provides a comprehensive overview of the pathophysiology of nociceptive pain and examines the current and emerging therapeutic targets aimed at modulating these processes for improved pain relief in clinical settings.