Translational Control: Orchestrating Gene Expression and Cellular Health
Received Date: Nov 03, 2025 / Published Date: Dec 01, 2025
Abstract
Translational control is a critical layer of gene expression regulation influencing protein synthesis and cellular responses. Key mechanisms include mRNA sequence and structure, RNA-binding proteins, ribosome dynamics, microRNAs, eIF2 phosphorylation, and polyadenylation. RNA structures, ribosomal stalling, and mRNA localization further fine-tune protein production. The interplay with mRNA decay pathways is also vital. Aberrant translational control contributes to disease, underscoring its significance for therapeutic intervention.
Keywords: Translational Control; Gene Expression Regulation; mRNA Structure; RNA-Binding Proteins; Ribosome; MicroRNAs; Protein Synthesis; Cellular Homeostasis; Disease Pathogenesis; Post-Transcriptional Regulation
Citation: Klein R (2025) Translational Control: Orchestrating Gene Expression and Cellular Health. cmb 71: 418. Doi: 10.4172/1165-158X.1000418
Copyright: © 2025 Robert Klein This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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