TRP Channels: Key Modulators of Pain Perception and Therapy
Received Date: Oct 01, 2025 / Published Date: Oct 29, 2025
Abstract
Transient Receptor Potential (TRP) channels are crucial for sensory transduction and cellular physiology, with significant roles in pain perception, thermosensation, and chemosensation. Key channels like TRPV1, TRPA1, and TRPM8 are implicated in detecting noxious stimuli and developing pain. Their modulation is explored as a therapeutic strategy for various pain conditions, including inflammatory and neuropathic pain. TRP channels also influence pain indirectly through cellular processes, and research focuses on subtype-specific functions and developing selective modulators, despite challenges in drug development.
Keywords: Transient Receptor Potential Channels脥戮 Pain Perception脥戮 Thermosensation脥戮 Chemosensation脥戮 Neuropathic Pain脥戮 Inflammatory Pain脥戮 TRP Channel Modulators脥戮 Nociception脥戮 TRPV1脥戮 TRPA1
Citation: Richardson P (2025) TRP Channels: Key Modulators of Pain Perception and Therapy. jpar 14: 793. Doi: 10.4172/2167-0846.1000793
Copyright: © 2025 Paul Richardson This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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