Tumor Suppressor Genes: Cancer Prevention and Therapeutic Targets
*Corresponding Author:Received Date: Oct 01, 2025 / Accepted Date: Oct 29, 2025 / Published Date: Oct 29, 2025
Citation: Park DM (2025) Tumor Suppressor Genes: Cancer Prevention and Therapeutic Targets. Int J Inflam Cancer Integr Ther 12: 362.DOI: 10.4172/2381-8727.1000362
Copyright: © 2025 Dr. Min-Jae Park This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Tumor suppressor genes are vital for preventing cancer by controlling cell growth and repair. Their loss or inactivation through mutation or epigenetic silencing is common in cancer. This review discusses the roles of key tumor suppressors like RB, TP53, BRCA1/2, PTEN, and APC in cell cycle regulation, DNA repair, and signaling pathways. Genomic instability and epigenetic alterations are highlighted as significant mechanisms of their inactivation. Emerging therapeutic strategies aim to restore tumor suppressor function for cancer treatment.
