Visceral Pain: Mechanisms, Pathways, and Modulation
Received Date: Sep 01, 2025 / Published Date: Sep 29, 2025
Abstract
Visceral pain arises from internal organs and involves specialized afferent pathways. Mechanisms include nociceptor activation by inflammatory mediators and mechanical/chemical stimuli, with signals transmitted via C-fibers and Aδ-fibers to the spinal cord. Central neuroplasticity contributes to chronic visceral pain. Inflammatory mediators sensitize nociceptors, and the enteric nervous system is vital for visceral sensory processing. Central sensitization amplifies pain signals, and TRP channels are crucial for stimulus detection. Gut microbiota influence pain via immune and nervous systems. Visceral hypersensitivity involves exaggerated responses, and psychological factors significantly modulate pain perception and chronicity.
Keywords: Visceral Pain脥戮 Nociceptors脥戮 Inflammatory Mediators脥戮 Enteric Nervous System脥戮 Central Sensitization脥戮 TRP Channels脥戮 Gut Microbiota脥戮 Visceral Hypersensitivity脥戮 Neurotransmitters脥戮 Descending Pain Modulation
Citation: Sato K (2025) Visceral Pain: Mechanisms, Pathways, and Modulation. jpar 14: 776. Doi: 10.4172/2167-0846.1000776
Copyright: 2025 Kenji Sato This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
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