ÖйúPÕ¾

Abstract

The use of transgenic mice to elucidate Alzheimer�s disease has been development in the last decade. Here we use APP/ Preseniline 1 transgenic mice to analyze inflammation and oxidative stress in transgenic mice compared with wild type. Microarray from inflammation proteins, Western-blot and RT-PCR are used to compare wild type and transgenic mice. Increase in pro-inflammatory proteins and decrease in anti-inflammatory proteins were detected in transgenic compared with wild type. Also, using western-blot assay we detect an increase of NMDA R1 and a decrease of NMDA R2 in transgenic mice compared with wild type in hippocampus, limbic and cerebellum. In conclusion, an unbalance between inflammatory and anti-inflammatory proteins and also different regions in brain use different pathways to protect viability of cell brain against the toxicity in Alzheimer�s disease.

Biography

Soraya L. Valles has completed her graduation in 1990 in biological science at the University of Valencia and had Ph.D. under supervision of Consuelo Guerri, until 1996. Dissertation was �Changes of astroglia intermediate filaments gene expression during rat brain development: Effect of alcohol exposure�. 1997 she won pre-doctoral award, school of medicine, University of Valencia. In 1997 she joined Eva Qwanstrom�s group at the Hallamshire Hospital, University of Sheffield, UK in interleukin-1 (IL-1) receptor complex. In 2000 returned to Spain at Department of Physiology, school of medicine, University of Valencia as lecturer, working in Alzheimer�s disease with Jose Vina�s group. Actually is independent laboratory director, studding Alzheimer�s diseases, inflammation and oxidative stress. She has about 25 international papers been referee of many health international journals.