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Journal of Biotechnology & Biomaterials
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In Association with
Preponderance of CTX-M type �²-lactamases producing bacterial isolates in river Yamuna
6th World Congress on Biotechnology
Mohammad Tahir Siddiqui, Aftab Hossain Mondal, Kehkashan Siddiqui and Qazi Mohd Rizwanul Haq
Jamia Millia Islamia, India
Posters-Accepted Abstracts: J Biotechnol Biomater
DOI:
Abstract
Antibiotic resistance has emerged as a great health care problem throughout the world. The �²-lactam antibiotics act as life saving drugs for their large contribution to fight against bacterial infections. These antibiotics are no longer as effective due to escalating resistance problem. One of the most efficient mechanisms of resistance towards �²-lactam antibiotics is the production of extended spectrum beta-lactamases (ESBLs). Among ESBLs, CTX-M type is most rapidly emerging and grievous groups. In aquatic environments bacteria from diverse origins are able to exchange their resistance genes through different genetic elements. In this present study, epidemiological survey of CTX-M type ESBL producing bacterial isolates from Delhi stretch of river Yamuna was carried out. Out of 402 isolates screened, 110 were found to be positive for ESBLs production through preliminary and PDCT analysis. Antibiotic susceptibility test against different class of antibiotics revealed a high level resistance among these isolates. The molecular analysis depicts the presence of blaCTX-M gene in majority of isolates tested. Presence of resistance genes in the aquatic environment to such an extent indicates the seriousness and severity of the problem. It raises the concern for the awareness of society and advance research to prevent emergence and dissemination of drug resistance in natural habitats.Biography
Email: tahir.sdq@gmail.com
